The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling

The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling

ABSTRACTDrug repurposing efforts led to the discovery of bactericidal activity in auranofin, a gold-containing drug used to treat rheumatoid arthritis. Auranofin kills Gram-positive bacteria by inhibiting thioredoxin reductase, an enzyme that scavenges reactive oxygen species (ROS). Despite the pres...

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Bibliographic Details
Main Authors: Dustin T. Maydaniuk, Brielle Martens, Sarah Iqbal, Andrew M. Hogan, Neil Lorente Cobo, Anna Motnenko, Dang Truong, Sajani H. Liyanage, Mingdi Yan, Gerd Prehna, Silvia T. Cardona
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:Microbiology Spectrum
Subjects:
Burkholderia
BarSeq
glutathione
ROS
synthetic lethality
antibiotic
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03201-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03201-23

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