The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling
ABSTRACTDrug repurposing efforts led to the discovery of bactericidal activity in auranofin, a gold-containing drug used to treat rheumatoid arthritis. Auranofin kills Gram-positive bacteria by inhibiting thioredoxin reductase, an enzyme that scavenges reactive oxygen species (ROS). Despite the pres...
Main Authors: | Dustin T. Maydaniuk, Brielle Martens, Sarah Iqbal, Andrew M. Hogan, Neil Lorente Cobo, Anna Motnenko, Dang Truong, Sajani H. Liyanage, Mingdi Yan, Gerd Prehna, Silvia T. Cardona |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2024-02-01
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Series: | Microbiology Spectrum |
Subjects: | |
Online Access: | https://journals.asm.org/doi/10.1128/spectrum.03201-23 |
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