A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis

A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis

Precisely controlled lymphocyte migration is critically required for immune surveillance and successful immune responses. Lymphocyte migration is strictly regulated by chemokines and chemokine receptors. Here we show that protein geranylgeranylation, a form of post-translational protein lipid modifi...

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Bibliographic Details
Main Authors: Gregory Swan, Jia Geng, Eunchong Park, Quanquan Ding, John Zhou, Ciana Walcott, Junyi J. Zhang, Hsin-I Huang, Gianna Elena Hammer, Donghai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
adaptive immune response
T cells
autoimmunity
lymphocyte migration
protein geranylgeranylation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.641188/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.641188/full

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