Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats

Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats

Abstract The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was...

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Bibliographic Details
Main Authors: Asmaa Badawy Darwish, Amira Mohamed Mohsen, Shaimaa ElShebiney, Rania Elgohary, Mostafa Mohamed Younis
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Piperine
Chitosan lipid nanoparticles
Diabetic cognitive deficit model
BDNF
Y-maze
Spatial memory
Online Access:https://doi.org/10.1038/s41598-024-58601-x

Internet

https://doi.org/10.1038/s41598-024-58601-x

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