Successful Treatment with Dabrafenib/Trametinib of a Malignantly Transformed and Metastasized BRAF V600E Mutant Pleiomorphic Xanthoastrocytoma: A Case Report and Review of the Literature

Successful Treatment with Dabrafenib/Trametinib of a Malignantly Transformed and Metastasized BRAF V600E Mutant Pleiomorphic Xanthoastrocytoma: A Case Report and Review of the Literature

Introduction: Pleiomorphic xanthoastrocytoma (PXA) is considered a low-grade glioma with a favorable prognosis following surgical resection. We present a case report of a BRAFV600E mutant malignantly transformed and disseminated PXA that was successfully treated with BRAF-/MEK-targeted therapy (dabr...

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Bibliographic Details
Main Authors: Elle Vermeulen, An-Sofie Vander Mijnsbrugge, Stefanie Brock, Freya Vaeyens, Iris Dirven, Abdulhamid Ciçek, William Marcelis, Samuel Klein, Michaël Bruneau, Bart Neyns, Johnny Duerinck
Format: Article
Language:English
Published: Karger Publishers 2024-01-01
Series:Case Reports in Oncology
Subjects:
pleiomorphic xanthoastrocytoma
anaplastic pleiomorphic xanthoastrocytoma
metastasic disease
brafv600e mutation
braf/mek inhibitors
targeted therapy
Online Access:https://beta.karger.com/Article/FullText/534731

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