The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications
The tumor microenvironment (TME) is a heterogeneous ecosystem comprising cancer cells, immune cells, stromal cells, and various non-cellular components, all of which play critical roles in controlling tumor progression and response to immunotherapies. Methyltransferase-like 3 (METTL3), the core comp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335774/full |
| _version_ | 1797349412979081216 |
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| author | Weiqi Su Lin Che Wenting Liao Huilin Huang |
| author_facet | Weiqi Su Lin Che Wenting Liao Huilin Huang |
| author_sort | Weiqi Su |
| collection | DOAJ |
| description | The tumor microenvironment (TME) is a heterogeneous ecosystem comprising cancer cells, immune cells, stromal cells, and various non-cellular components, all of which play critical roles in controlling tumor progression and response to immunotherapies. Methyltransferase-like 3 (METTL3), the core component of N6-methyladenosine (m6A) writer, is frequently associated with abnormalities in the m6A epitranscriptome in different cancer types, impacting both cancer cells and the surrounding TME. While the impact of METTL3 on cancer cells has been extensively reviewed, its roles in TME and anti-cancer immunity have not been comprehensively summarized. This review aims to systematically summarize the functions of METTL3 in TME, particularly its effects on tumor-infiltrating immune cells. We also elaborate on the underlying m6A-dependent mechanism. Additionally, we discuss ongoing endeavors towards developing METTL3 inhibitors, as well as the potential of targeting METTL3 to bolster the efficacy of immunotherapy. |
| first_indexed | 2024-03-08T12:29:53Z |
| format | Article |
| id | doaj.art-1a6e86b05fb34a998a86e5ffa3a67e0b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T12:29:53Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1a6e86b05fb34a998a86e5ffa3a67e0b2024-01-22T04:17:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011510.3389/fimmu.2024.13357741335774The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implicationsWeiqi SuLin CheWenting LiaoHuilin HuangThe tumor microenvironment (TME) is a heterogeneous ecosystem comprising cancer cells, immune cells, stromal cells, and various non-cellular components, all of which play critical roles in controlling tumor progression and response to immunotherapies. Methyltransferase-like 3 (METTL3), the core component of N6-methyladenosine (m6A) writer, is frequently associated with abnormalities in the m6A epitranscriptome in different cancer types, impacting both cancer cells and the surrounding TME. While the impact of METTL3 on cancer cells has been extensively reviewed, its roles in TME and anti-cancer immunity have not been comprehensively summarized. This review aims to systematically summarize the functions of METTL3 in TME, particularly its effects on tumor-infiltrating immune cells. We also elaborate on the underlying m6A-dependent mechanism. Additionally, we discuss ongoing endeavors towards developing METTL3 inhibitors, as well as the potential of targeting METTL3 to bolster the efficacy of immunotherapy.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335774/fullmethyltransferase-like 3 (METTL3)N6-methyladenosine (m6A)tumor-infiltrating immune cells (TICs)small molecular inhibitorscancer immunotherapyimmune checkpoint inhibitors (ICI) |
| spellingShingle | Weiqi Su Lin Che Wenting Liao Huilin Huang The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications Frontiers in Immunology methyltransferase-like 3 (METTL3) N6-methyladenosine (m6A) tumor-infiltrating immune cells (TICs) small molecular inhibitors cancer immunotherapy immune checkpoint inhibitors (ICI) |
| title | The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications |
| title_full | The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications |
| title_fullStr | The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications |
| title_full_unstemmed | The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications |
| title_short | The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications |
| title_sort | rna m6a writer mettl3 in tumor microenvironment emerging roles and therapeutic implications |
| topic | methyltransferase-like 3 (METTL3) N6-methyladenosine (m6A) tumor-infiltrating immune cells (TICs) small molecular inhibitors cancer immunotherapy immune checkpoint inhibitors (ICI) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335774/full |
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