Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
The arylamine N-acetyltransferase 2 (NAT2) enzymes detoxify a wide range of naturally occurring xenobiotics including carcinogens and drugs. Point mutations in the NAT2 gene result in the variant alleles M1 (NAT2 *5A), M2 (NAT2*6A), M3 (NAT2*7) and M4 (NAT2 *14A) from the wild-type WT (NAT2 *4) alle...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2012-01-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500003 |
| _version_ | 1828733401855688704 |
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| author | Amjad Mahasneh Amal Jubaili Ahmed El Bateiha Mohammad Al-Ghazo Ismail Matalka Mousa Malkawi |
| author_facet | Amjad Mahasneh Amal Jubaili Ahmed El Bateiha Mohammad Al-Ghazo Ismail Matalka Mousa Malkawi |
| author_sort | Amjad Mahasneh |
| collection | DOAJ |
| description | The arylamine N-acetyltransferase 2 (NAT2) enzymes detoxify a wide range of naturally occurring xenobiotics including carcinogens and drugs. Point mutations in the NAT2 gene result in the variant alleles M1 (NAT2 *5A), M2 (NAT2*6A), M3 (NAT2*7) and M4 (NAT2 *14A) from the wild-type WT (NAT2 *4) allele. The current study was aimed at screening genetic polymorphisms of NAT2 gene in 49 lung cancer patients, 54 colorectal cancer patients and 99 cancer-free controls, using PCR-RFLP. There were significant differences in allele frequencies between lung cancer patients and controls in the WT, M2 and M3 alleles (p < 0.05). However, only M2 and M3 allele frequencies were different between colorectal cancer patients and controls (p < 0.05). There was a marginal significant difference in the distribution of rapid and slow acetylator genotypes between lung cancer patients and controls (p = 0.06 and p = 0.05, respectively), but not between colorectal cancer patients and controls (p = 1.0 and p = 0.95, respectively). Risk of lung cancer development was found to be lower in slow acetylators [odds ratio (OR): 0.51, 95% confidence interval (95% CI): 0.25, 1.02, p-value = 0.07]. No effect was observed in case of colorectal cancer. Our results showed that NAT2 genotypes and phenotypes might be involved in lung cancer but not colorectal cancer susceptibility in Jordan. |
| first_indexed | 2024-04-12T22:29:07Z |
| format | Article |
| id | doaj.art-1a7127b7bf1d4bd6ac49f934210c6ab0 |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-04-12T22:29:07Z |
| publishDate | 2012-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-1a7127b7bf1d4bd6ac49f934210c6ab02022-12-22T03:14:01ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852012-01-01354725733Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancerAmjad MahasnehAmal JubailiAhmed El BateihaMohammad Al-GhazoIsmail MatalkaMousa MalkawiThe arylamine N-acetyltransferase 2 (NAT2) enzymes detoxify a wide range of naturally occurring xenobiotics including carcinogens and drugs. Point mutations in the NAT2 gene result in the variant alleles M1 (NAT2 *5A), M2 (NAT2*6A), M3 (NAT2*7) and M4 (NAT2 *14A) from the wild-type WT (NAT2 *4) allele. The current study was aimed at screening genetic polymorphisms of NAT2 gene in 49 lung cancer patients, 54 colorectal cancer patients and 99 cancer-free controls, using PCR-RFLP. There were significant differences in allele frequencies between lung cancer patients and controls in the WT, M2 and M3 alleles (p < 0.05). However, only M2 and M3 allele frequencies were different between colorectal cancer patients and controls (p < 0.05). There was a marginal significant difference in the distribution of rapid and slow acetylator genotypes between lung cancer patients and controls (p = 0.06 and p = 0.05, respectively), but not between colorectal cancer patients and controls (p = 1.0 and p = 0.95, respectively). Risk of lung cancer development was found to be lower in slow acetylators [odds ratio (OR): 0.51, 95% confidence interval (95% CI): 0.25, 1.02, p-value = 0.07]. No effect was observed in case of colorectal cancer. Our results showed that NAT2 genotypes and phenotypes might be involved in lung cancer but not colorectal cancer susceptibility in Jordan.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500003NAT2lung cancercolorectal cancerpolymorphisms |
| spellingShingle | Amjad Mahasneh Amal Jubaili Ahmed El Bateiha Mohammad Al-Ghazo Ismail Matalka Mousa Malkawi Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer Genetics and Molecular Biology NAT2 lung cancer colorectal cancer polymorphisms |
| title | Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer |
| title_full | Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer |
| title_fullStr | Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer |
| title_full_unstemmed | Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer |
| title_short | Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer |
| title_sort | polymorphisms of arylamine n acetyltransferase2 and risk of lung and colorectal cancer |
| topic | NAT2 lung cancer colorectal cancer polymorphisms |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500003 |
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