TERT Promoter Mutations and rs2853669 Polymorphism: Useful Markers for Clinical Outcome Stratification of Patients With Oral Cavity Squamous Cell Carcinoma

TERT Promoter Mutations and rs2853669 Polymorphism: Useful Markers for Clinical Outcome Stratification of Patients With Oral Cavity Squamous Cell Carcinoma

ObjectiveTo date, no useful prognostic biomarker exists for patients with oral squamous cell carcinoma (OCSCC), a tumour with uncertain biological behaviour and subsequent unpredictable clinical course. We aim to investigate the prognostic significance of two recurrent somatic mutations (-124 C&...

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Main Authors: Silvia Giunco, Paolo Boscolo-Rizzo, Enrica Rampazzo, Giancarlo Tirelli, Lara Alessandrini, Roberto Di Carlo, Marco Rossi, Piero Nicolai, Anna Menegaldo, Valentina Carraro, Margherita Tofanelli, Luigia Bandolin, Giacomo Spinato, Enzo Emanuelli, Monica Mantovani, Marco Stellin, Rossana Bussani, Angelo Paolo Dei Tos, Maria Guido, Marzia Morello, Jonathan Fussey, Giovanni Esposito, Jerry Polesel, Anita De Rossi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
oral cavity squamous cell carcinoma (OCSCC)
telomerase
TERT promoter mutations
SNP rs2853669
telomere
prognostic biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.782658/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.782658/full

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