N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease

N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease

Niemann-Pick disease type C1 (NPC1) is a fatal, neurodegenerative, cholesterol storage disorder. With new therapeutics in clinical trials, there is an urgency to improve diagnostics and monitor therapeutic efficacy with biomarkers. In this study, we sought to define the structure of an unknown lipid...

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Bibliographic Details
Main Authors: Rohini Sidhu, Yawo Mondjinou, Mingxing Qian, Haowei Song, Arun Babu Kumar, Xinying Hong, Fong-Fu Hsu, Dennis J. Dietzen, Nicole M. Yanjanin, Forbes D. Porter, Elizabeth Berry-Kravis, Charles H. Vite, Michael H. Gelb, Jean E. Schaffer, Daniel S. Ory, Xuntian Jiang
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Journal of Lipid Research
Subjects:
Niemann-Pick disease type C
mass spectrometry
structural identification
lysoSM-509
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322355

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http://www.sciencedirect.com/science/article/pii/S0022227520322355

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