JC Virus T-Antigen in Colorectal Cancer Is Associated with p53 Expression and Chromosomal Instability, Independent of CpG Island Methylator Phenotype

JC Virus T-Antigen in Colorectal Cancer Is Associated with p53 Expression and Chromosomal Instability, Independent of CpG Island Methylator Phenotype

JC virus has a transforming gene encoding JC virus T-antigen (JCVT). JCVT may inactivate wild-type p53, cause chromosomal instability (CIN), and stabilize β-catenin. A link between JCVT and CpG island methylator phenotype (CIMP) has been suggested. However, no large-scale study has examined the rela...

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Bibliographic Details
Main Authors: Katsuhiko Nosho, Kaori Shima, Shoko Kure, Natsumi Irahara, Yoshifumi Baba, Li Chen, Gregory J. Kirkner, Charles S. Fuchs, Shuji Ogino
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609800924

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http://www.sciencedirect.com/science/article/pii/S1476558609800924

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