METTL3 Regulates Ossification of the Posterior Longitudinal Ligament via the lncRNA XIST/miR-302a-3p/USP8 Axis

METTL3 Regulates Ossification of the Posterior Longitudinal Ligament via the lncRNA XIST/miR-302a-3p/USP8 Axis

The prevalence of ossification of the posterior longitudinal ligament (OPLL) is increasing, and currently there is no effective medical treatment for OPLL. Methyltransferase like 3 (METTL3), one of the components of the N6-methyladenosine (m6A) methyltransferase complex, regulates gene expression vi...

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Bibliographic Details
Main Authors: Xiaoqiu Yuan, Lei Shi, Yongfei Guo, Jingchuan Sun, Jinhao Miao, Jiangang Shi, Yu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ossification of the posterior longitudinal ligament
long non-coding RNA
methyltransferase like 3
m6A methylation
miR-302a-3p
X-inactive specific transcript
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.629895/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.629895/full

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