Depolarization-Induced 65Zinc Influx into Cultured Cortical Neurons

Depolarization-Induced 65Zinc Influx into Cultured Cortical Neurons

Toxic Zn2+ influx may be a key mechanism underlying selective neuronal death after transient global ischemia in rats. To identify routes responsible for neuronal Zn2+ influx, we measured the accumulation of 65Zn2+ into cultured murine cortical cells under depolarizing conditions (60 mM K+) associate...

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Bibliographic Details
Main Authors: Christian T. Sheline, Howard S. Ying, Chris S. Ling, Lorella M.T. Canzoniero, Dennis W. Choi
Format: Article
Language:English
Published: Elsevier 2002-06-01
Series:Neurobiology of Disease
Subjects:
global ischemia
neuronal death
excitotoxicity
calcium channels
glutamate
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102904973

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http://www.sciencedirect.com/science/article/pii/S0969996102904973

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