BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association

Summary: To elicit apoptosis, BAX metamorphoses from an inert cytosolic monomer into homo-oligomers that permeabilize the mitochondrial outer membrane (MOM). A long-standing puzzle is that BH3 domains apparently activate BAX by not only its canonical groove but also a proposed site involving helices...

Full description

Bibliographic Details
Main Authors: Michael A. Dengler, Adeline Y. Robin, Leonie Gibson, Mark X. Li, Jarrod J. Sandow, Sweta Iyer, Andrew I. Webb, Dana Westphal, Grant Dewson, Jerry M. Adams
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719303560

Internet

http://www.sciencedirect.com/science/article/pii/S2211124719303560

Similar Items