The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy

The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy

Glutamate is the brain’s main excitatory neurotransmitter. Glutamatergic neurons primarily compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and inhibitory activities may result in epilepsy or other neurological and psychiatric conditions. Among glutamate receptor...

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Bibliographic Details
Main Authors: Fabio Perversi, Cinzia Costa, Angelo Labate, Simona Lattanzi, Claudio Liguori, Marta Maschio, Stefano Meletti, Lino Nobili, Francesca Felicia Operto, Andrea Romigi, Emilio Russo, Carlo Di Bonaventura
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Neurology
Subjects:
AMPA receptors
AMPA antagonists
glutamate
perampanel
epilepsy
sleep
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1182304/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2023.1182304/full

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