Ablation of Cbl-b and c-Cbl in dendritic cells causes spontaneous liver cirrhosis via altering multiple properties of CD103+ cDC1s

Ablation of Cbl-b and c-Cbl in dendritic cells causes spontaneous liver cirrhosis via altering multiple properties of CD103+ cDC1s

Abstract The Casitas B-lineage lymphoma (Cbl) family proteins are E3 ubiquitin ligases implicated in the regulation of various immune cells. However, their function in dendritic cells (DCs) remains unclear. To investigate the role of Cbl family members in DCs, we created dendritic cell double-defici...

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Bibliographic Details
Main Authors: Fei Xu, Chen Liu, Yongli Dong, Wenyan Wu, Jie Xu, Yunqiu Yan, Yu Shao, Chuangli Hao, Yi Yang, Jinping Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2022-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00953-2

Internet

https://doi.org/10.1038/s41420-022-00953-2

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