Distinct spatial distribution and roles of Kupffer cells and monocyte-derived macrophages in mouse acute liver injury

Distinct spatial distribution and roles of Kupffer cells and monocyte-derived macrophages in mouse acute liver injury

Macrophages are key regulators of inflammation and repair, but their heterogeneity and multiple roles in the liver are not fully understood. We aimed herein to map the intrahepatic macrophage populations and their function(s) during acute liver injury. We used flow cytometry, gene expression analysi...

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Bibliographic Details
Main Authors: Manuel Flores Molina, Mohamed N. Abdelnabi, Sabrina Mazouz, Deborah Villafranca-Baughman, Vincent Quoc-Huy Trinh, Shafi Muhammad, Nathalie Bédard, David Osorio Laverde, Ghada S. Hassan, Adriana Di Polo, Naglaa H. Shoukry
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
liver
macrophage
acute injury
CCl4 (carbon tetra chloride)
Kupffer cell (KC)
monocyte-derived macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.994480/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.994480/full

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