A novel respiratory syncytial virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models.

A novel respiratory syncytial virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models.

Illness associated with Respiratory Syncytial Virus (RSV) remains an unmet medical need in both full-term infants and older adults. The fusion glycoprotein (F) of RSV, which plays a key role in RSV infection and is a target of neutralizing antibodies, is an attractive vaccine target for inducing RSV...

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Bibliographic Details
Main Authors: Stacie L Lambert, Shahin Aslam, Elizabeth Stillman, Mia MacPhail, Christine Nelson, Bodrey Ro, Rosemary Sweetwood, Yuk Man Lei, Jennifer C Woo, Roderick S Tang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4368639?pdf=render

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http://europepmc.org/articles/PMC4368639?pdf=render

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