Synthetic Glabridin Derivatives Inhibit LPS-Induced Inflammation via MAPKs and NF-κB Pathways in RAW264.7 Macrophages

Synthetic Glabridin Derivatives Inhibit LPS-Induced Inflammation via MAPKs and NF-κB Pathways in RAW264.7 Macrophages

Glabridin is a polyphenolic compound with reported anti-inflammatory and anti-oxidative effects. In the previous study, we synthesized glabridin derivatives—HSG4112, (S)-HSG4112, and HGR4113—based on the structure–activity relationship study of glabridin to improve its biological efficacy and chemic...

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Bibliographic Details
Main Authors: Jaejin Shin, Leo Sungwong Choi, Hyun Ju Jeon, Hyeong Min Lee, Sang Hyo Kim, Kwan-Woo Kim, Wonmin Ko, Hyuncheol Oh, Hyung Soon Park
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
glabridin derivatives
HSG4112 (vutiglabridin)
HGR4113
LPS-stimulated macrophage
anti-inflammation
NF-κB
Online Access:https://www.mdpi.com/1420-3049/28/5/2135

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https://www.mdpi.com/1420-3049/28/5/2135

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