Synthetic Glabridin Derivatives Inhibit LPS-Induced Inflammation via MAPKs and NF-κB Pathways in RAW264.7 Macrophages

Synthetic Glabridin Derivatives Inhibit LPS-Induced Inflammation via MAPKs and NF-κB Pathways in RAW264.7 Macrophages

Glabridin is a polyphenolic compound with reported anti-inflammatory and anti-oxidative effects. In the previous study, we synthesized glabridin derivatives—HSG4112, (S)-HSG4112, and HGR4113—based on the structure–activity relationship study of glabridin to improve its biological efficacy and chemic...

Celý popis

Podrobná bibliografie
Hlavní autoři: Jaejin Shin, Leo Sungwong Choi, Hyun Ju Jeon, Hyeong Min Lee, Sang Hyo Kim, Kwan-Woo Kim, Wonmin Ko, Hyuncheol Oh, Hyung Soon Park
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2023-02-01
Edice:Molecules
Témata:
glabridin derivatives
HSG4112 (vutiglabridin)
HGR4113
LPS-stimulated macrophage
anti-inflammation
NF-κB
On-line přístup:https://www.mdpi.com/1420-3049/28/5/2135

Internet

https://www.mdpi.com/1420-3049/28/5/2135

Podobné jednotky