The driver role of JAK‐STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy‐ and castration‐resistant prostate cancer

The driver role of JAK‐STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy‐ and castration‐resistant prostate cancer

Abstract Background Lineage plasticity in prostate cancer (PCa) has emerged as an important mechanism leading to the onset of therapy‐ and castration‐resistant PCa (t‐CRPC), which is closely associated with cancer stem cell (CSC) activity. This study is to identify critical driver(s) with mechanism...

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Bibliographic Details
Main Authors: U‐Ging Lo, Yu‐An Chen, Junjie Cen, Su Deng, Junghang Luo, Haiyen Zhau, Lin Ho, Chih‐Ho Lai, Ping Mu, Leland W.K. Chung, Jer‐Tsong Hsieh
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Clinical and Translational Medicine
Subjects:
IFIT5
interferon signalling
JAK
STAT1
targeted therapy
therapy‐ and castration‐resistant prostate cancer
Online Access:https://doi.org/10.1002/ctm2.978

Internet

https://doi.org/10.1002/ctm2.978

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