Novel <i>N</i>-Arylsulfonylindoles Targeted as Ligands of the 5-HT<sub>6</sub> Receptor. Insights on the Influence of C-5 Substitution on Ligand Affinity

Novel <i>N</i>-Arylsulfonylindoles Targeted as Ligands of the 5-HT<sub>6</sub> Receptor. Insights on the Influence of C-5 Substitution on Ligand Affinity

A new series of twenty-two C-5 substituted <i>N</i>-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT<sub>6</sub> receptor affinity. Eleven compounds showed moderate to high affinity at the receptor (<i>K</i><s...

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Bibliographic Details
Main Authors: Loreto Arrieta-Rodríguez, Daniela Espinoza-Rosales, Gonzalo Vera, Young Hwa Cho, David Cabezas, David Vásquez-Velásquez, Jaime Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
arylsulfonylindoles
5-HT<sub>6</sub> receptor
serotonergic ligands
docking
CoMFA
CoMSIA
Online Access:https://www.mdpi.com/1424-8247/14/6/528

Internet

https://www.mdpi.com/1424-8247/14/6/528

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