Regulation of CD8+ T cell responses to retinal antigen by local FoxP3+ regulatory T cells

While pathogenic CD4 T cells are well known mediators of autoimmune uveoretinitis, CD8 T cells can also be uveitogenic. Since preliminary studies indicated that C57BL/6 mice were minimally susceptible to autoimmune uveoretinitis induction by CD8 T cells, the basis of the retinal disease resistance w...

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Bibliographic Details
Main Authors: Scott W McPherson, Neal D Heuss, Dale S Gregerson
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00166/full