Cavin1 Deficiency Causes Disorder of Hepatic Glycogen Metabolism and Neonatal Death by Impacting Fenestrations in Liver Sinusoidal Endothelial Cells

Cavin1 Deficiency Causes Disorder of Hepatic Glycogen Metabolism and Neonatal Death by Impacting Fenestrations in Liver Sinusoidal Endothelial Cells

Abstract It has been reported that Cavin1 deficiency causes lipodystrophy in both humans and mice by affecting lipid metabolism. The ablation of Cavin1 in rodents also causes a significant deviation from Mendelian ratio at weaning in a background‐dependent manner, suggesting the presence of undiscov...

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Bibliographic Details
Main Authors: Zhuang Wei, Jigang Lei, Feng Shen, Yuxiang Dai, Yan Sun, Yilian Liu, Yan Dai, Zhijie Jian, Shilong Wang, Zhengjun Chen, Kan Liao, Shangyu Hong
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Advanced Science
Subjects:
Cavin1
congenital generalized lipodystrophy type 4
fenestration
glycogen metabolism
liver sinusoidal endothelial cells
Online Access:https://doi.org/10.1002/advs.202000963

Internet

https://doi.org/10.1002/advs.202000963

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