The Effect of Cell Morphology on the Permeability of the Nuclear Envelope to Diffusive Factors

The Effect of Cell Morphology on the Permeability of the Nuclear Envelope to Diffusive Factors

A recent advance in understanding stem cell differentiation is that the cell is able to translate its morphology, i.e., roundish or spread, into a fate decision. We hypothesize that strain states in the nuclear envelope (NE) cause changes in the structure of the nuclear pore complexes. This induces...

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Bibliographic Details
Main Authors: Alberto García-González, Emanuela Jacchetti, Roberto Marotta, Marta Tunesi, José F. Rodríguez Matas, Manuela T. Raimondi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
nuclear pore complex
passive diffusion
nuclear envelope permeability
stem cell differentiation
finite element modeling
scanning transmission electron microscopy
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00925/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00925/full

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