ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA

Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A—also called progerin—causes Hutchinson–Gilford progeria syndrome a well-known premature aging disease. Minor levels of proger...

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Bibliographic Details
Main Authors: Moritz Messner, Santhosh Kumar Ghadge, Thomas Maurer, Michael Graber, Simon Staggl, Sarah Christine Maier, Gerhard Pölzl, Marc-Michael Zaruba
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
ZMPSTE24
lamin A/C
progerin
aging
inflammation
Online Access:https://www.mdpi.com/2073-4409/9/9/1981

Internet

https://www.mdpi.com/2073-4409/9/9/1981

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