Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in Leishmania donovani

Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in Leishmania donovani

ABSTRACT The 90-kDa heat shock protein (HSP90) of eukaryotes is a highly abundant and essential chaperone required for the maturation of regulatory and signal proteins. In the protozoan parasite Leishmania donovani, causative agent of the fatal visceral leishmaniasis, HSP90 activity is essential for...

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Bibliografske podrobnosti
Main Authors: Eugenia Bifeld, Stephan Lorenzen, Katharina Bartsch, Juan-José Vasquez, T. Nicolai Siegel, Joachim Clos
Format: Article
Jezik:English
Izdano: American Society for Microbiology 2018-10-01
Serija:mSystems
Teme:
HSP90
Leishmania donovani
radicicol
ribosome profiling
Online dostop:https://journals.asm.org/doi/10.1128/msystems.00214-18

Internet

https://journals.asm.org/doi/10.1128/msystems.00214-18

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