Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo

Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo

Alzheimer’s disease (AD) is a complex and widespread condition, still not fully understood and with no cure yet. Amyloid beta (Aβ) peptide is suspected to be a major cause of AD, and therefore, simultaneously blocking its formation and aggregation by inhibition of the enzymes BACE-1 (β-secretase) an...

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Bibliographic Details
Main Authors: Noa Stern, Alexandra Gacs, Enikő Tátrai, Beáta Flachner, István Hajdú, Krisztina Dobi, István Bágyi, György Dormán, Zsolt Lőrincz, Sándor Cseh, Attila Kígyós, József Tóvári, Amiram Goldblum
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
multi-targeting
acetylcholinesterase (AChE)
β-secretase (BACE-1)
dual inhibitors
in silico
enzyme inhibition
Online Access:https://www.mdpi.com/1422-0067/23/21/13098

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https://www.mdpi.com/1422-0067/23/21/13098

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