Unravelling the role of Sildenafil and SB204741 in suppressing fibrotic potential of peritoneal fibroblasts obtained from PD patients

Unravelling the role of Sildenafil and SB204741 in suppressing fibrotic potential of peritoneal fibroblasts obtained from PD patients

Introduction: Peritoneal fibrosis (PF) results in technique failure in peritoneal dialysis (PD) patients. Peritoneal fibroblasts are characterized by increase in the ACTA2 gene, responsible for alpha smooth muscle actin (α−SΜΑ), extracellular matrix (ECM) production, and inflammatory cytokines produ...

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Bibliographic Details
Main Authors: Saurabh Chaturvedi, Harshit Singh, Vikas Agarwal, Akhilesh Jaiswal, Narayan Prasad
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
peritoneal fibrosis
serotonin
TGF-β1
sildenafil
SB204741
ACTA2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1279330/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1279330/full

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