Hypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae.

Hypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae.

Hypertrophic differentiation of growth plate chondrocytes induces angiogenesis which alleviates hypoxia normally present in cartilage. In the current study, we aim to determine whether alleviation of hypoxia is merely a downstream effect of hypertrophic differentiation as previously described or whe...

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Bibliographic Details
Main Authors: Jeroen C H Leijten, Liliana S Moreira Teixeira, Ellie B M Landman, Clemens A van Blitterswijk, Marcel Karperien
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3503827?pdf=render

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http://europepmc.org/articles/PMC3503827?pdf=render

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