Gene editing of the multi-copy H2A.B gene and its importance for fertility

Gene editing of the multi-copy H2A.B gene and its importance for fertility

Abstract Background Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene expression. The histone variant H2A.B, H2A.B.3 in mice, appeared late in evolution and is most highly expressed in the testis. In...

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Bibliographic Details
Main Authors: Nur Diana Anuar, Sebastian Kurscheid, Matt Field, Lei Zhang, Edward Rebar, Philip Gregory, Thierry Buchou, Josephine Bowles, Peter Koopman, David J. Tremethick, Tatiana A. Soboleva
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Genome Biology
Subjects:
Chromatin
Histone variants
H2A.B
RNA polymerase II
Pre-mRNA splicing
Splicing speckles
Online Access:http://link.springer.com/article/10.1186/s13059-019-1633-3

Internet

http://link.springer.com/article/10.1186/s13059-019-1633-3

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