Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice

Abstract Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3...

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Bibliographic Details
Main Authors: Shujuan Zhang, Xiaoguang Li, Zhouyi Wang, Yanchao Liu, Yuan Gao, Lu Tan, Enjie Liu, Qiuzhi Zhou, Cheng Xu, Xin Wang, Gongping Liu, Haote Chen, Jian-Zhi Wang
Format: Article
Language:English
Published: Nature Portfolio 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01811-3