MSC therapy ameliorates experimental gouty arthritis hinting an early COX-2 induction

MSC therapy ameliorates experimental gouty arthritis hinting an early COX-2 induction

ObjectiveThe specific effect of Adipose-Derived Mesenchymal Stem Cells (Ad-MSC) on acute joint inflammation, where the response mostly depends on innate immunity activation, remains elusive. The pathogenesis of gouty arthritis, characterized by the deposition of monosodium urate (MSU) crystals in th...

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Bibliographic Details
Main Authors: Juan Pablo Medina, Ismael Bermejo-Álvarez, Sandra Pérez-Baos, Rosa Yáñez, María Fernández-García, Damián García-Olmo, Aránzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stem cells (MSCs)
innate inflammation
macrophage
polarization
inflammasome
prostaglandin E2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1193179/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1193179/full

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