Cryptotanshinone inhibits PFK-mediated aerobic glycolysis by activating AMPK pathway leading to blockade of cutaneous melanoma

Cryptotanshinone inhibits PFK-mediated aerobic glycolysis by activating AMPK pathway leading to blockade of cutaneous melanoma

Abstract Background Cutaneous melanoma is a kind of skin malignancy with low morbidity but high mortality. Cryptotanshinone (CPT), an important component of salvia miltiorrhiza has potent anti-tumor activity and also indicates therapeutic effect on dermatosis. So we thought that CPT maybe a potentia...

Full description

Bibliographic Details
Main Authors: Qiong Chen, Yang Liu, Yunxuan Zhu, Ziyan Zhu, Jueyao Zou, Yanhong Pan, Yin Lu, Wenxing Chen
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Chinese Medicine
Subjects:
Cryptotanshinone
Aerobic glycolysis
Melanoma
PFK
AMPK
HIF-1α
Online Access:https://doi.org/10.1186/s13020-024-00913-1

Internet

https://doi.org/10.1186/s13020-024-00913-1

Similar Items