Parvovirus B19 Uncoating Occurs in the Cytoplasm without Capsid Disassembly and It Is Facilitated by Depletion of Capsid-Associated Divalent Cations

Parvovirus B19 Uncoating Occurs in the Cytoplasm without Capsid Disassembly and It Is Facilitated by Depletion of Capsid-Associated Divalent Cations

Human parvovirus B19 (B19V) traffics to the cell nucleus where it delivers the genome for replication. The intracellular compartment where uncoating takes place, the required capsid structural rearrangements and the cellular factors involved remain unknown. We explored conditions that trigger uncoat...

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Bibliographic Details
Main Authors: Oliver Caliaro, Andrea Marti, Nico Ruprecht, Remo Leisi, Suriyasri Subramanian, Susan Hafenstein, Carlos Ros
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Viruses
Subjects:
B19V
parvovirus
uncoating
divalent cations
capsid stability
genome externalization
trafficking
nuclear targeting
Online Access:https://www.mdpi.com/1999-4915/11/5/430

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https://www.mdpi.com/1999-4915/11/5/430

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