Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD)

Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD)

Introduction: Hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes are major therapeutic targets of anemia and ischemic/hypoxia diseases. To overcome safety issues, liver failure, and problems associated with on-/off-targets, natural products due to their novel and unique structure...

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Bibliographic Details
Main Authors: Abrar Mohammad Sayaf, Saif Ullah Khalid, Jawad Ahmed Hameed, Abdulrahman Alshammari, Abbas Khan, Anwar Mohammad, Saeed Alghamdi, Dong-Qing Wei, KarKheng Yeoh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
HIF
molecular screening
natural products
molecular simulation
binding free energy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1202128/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1202128/full

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