Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD

Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that exist on a disease spectrum due to pathological, clinical and genetic overlap. In up to 97% of ALS cases and ~50% of FTLD cases, the primary pathological protein observed in affected...

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Bibliographic Details
Main Authors: Alistair Wood, Yuval Gurfinkel, Nicole Polain, Wesley Lamont, Sarah Lyn Rea
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
frontotemporal lobar degeneration
TARDBP/TDP-43
RNA metabolism
mitochondrial dysfunction
proteostasis
Online Access:https://www.mdpi.com/1422-0067/22/9/4705

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https://www.mdpi.com/1422-0067/22/9/4705

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