Retinoic acid-loaded PLGA nanocarriers targeting cell cholesterol potentialize the antitumour effect of PD-L1 antibody by preventing epithelial-mesenchymal transition mediated by M2-TAM in colorectal cancer

Retinoic acid-loaded PLGA nanocarriers targeting cell cholesterol potentialize the antitumour effect of PD-L1 antibody by preventing epithelial-mesenchymal transition mediated by M2-TAM in colorectal cancer

Tumour-associated macrophages (TAMs) often promote cancer progression through immunosuppression in the tumour microenvironment (TME). However, the signalling pathways crosstalk responsible for this mechanism remain unclear. The aim of our study was to investigate whether the interaction between TAMs...

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Bibliographic Details
Main Authors: Raimundo Fernandes de Araújo Júnior, George A Lira, Timo Schomann, Rômulo S Cavalcante, Natalia Feitosa Vilar, Regina Célia Monteiro de Paula, Raelle Ferreira Gomes, Chih Kit Chung, Carla Jorquera-Cordero, Olena Vepris, Alan B Chan, Luis J. Cruz
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Translational Oncology
Subjects:
Immunomodulation
M2-like macrophages
PLGA nanoparticles
Anti-PD-L1
STAT3/NF-κB
Metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323000335

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http://www.sciencedirect.com/science/article/pii/S1936523323000335

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