Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2.

Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2.

Therapeutic intervention aimed at reactivation of fetal hemoglobin protein (HbF) is a promising approach for ameliorating sickle cell disease (SCD) and β-thalassemia. Previous studies showed genetic knockdown of histone deacetylase (HDAC) 1 or 2 is sufficient to induce HbF. Here we show that ACY-957...

Full description

Bibliographic Details
Main Authors: Jeffrey R Shearstone, Olga Golonzhka, Apurva Chonkar, David Tamang, John H van Duzer, Simon S Jones, Matthew B Jarpe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4830539?pdf=render

Internet

http://europepmc.org/articles/PMC4830539?pdf=render

Similar Items