L-Ascorbic Acid and α-Tocopherol Synergistically Triggers Apoptosis Inducing Antileukemic Effects of Arsenic Trioxide via Oxidative Stress in Human Acute Promyelocytic Leukemia Cells

L-Ascorbic Acid and α-Tocopherol Synergistically Triggers Apoptosis Inducing Antileukemic Effects of Arsenic Trioxide via Oxidative Stress in Human Acute Promyelocytic Leukemia Cells

Chemosensitization is an effective strategy to overcome the drawbacks of arsenic trioxide (As2O3) treatment, which may be possible through the use of dietary supplements in combination. The present investigation evaluates the synergistic mechanism of action of vitamins, such as L-ascorbic acid (L-AA...

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Bibliographic Details
Main Authors: Radhakrishnan Chandraprabha Vineetha, Sreedharan Hariharan, Abdul Jaleel, Mahesh Chandran, Raveendran Harikumaran Nair
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
acute promyelocytic leukemia
arsenic trioxide
HL-60 cells
L-ascorbic acid
α-tocopherol
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00065/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00065/full

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