Fetal and maternal NLRP3 signaling is required for preterm labor and birth

Fetal and maternal NLRP3 signaling is required for preterm labor and birth

Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by invading bacteria. However, the molecular mechanisms underlying this hostile immune response remain unclear. Here, we used...

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Bibliographic Details
Main Authors: Kenichiro Motomura, Roberto Romero, Jose Galaz, Li Tao, Valeria Garcia-Flores, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Derek Miller, Pedro Gutierrez-Contreras, Marcelo Farias-Jofre, Siddhesh Aras, Lawrence I. Grossman, Adi L. Tarca, Nardhy Gomez-Lopez
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-08-01
Series:JCI Insight
Subjects:
Immunology
Reproductive biology
Online Access:https://doi.org/10.1172/jci.insight.158238

Internet

https://doi.org/10.1172/jci.insight.158238

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