Mechanism and Therapeutic Targets of c-Jun-N-Terminal Kinases Activation in Nonalcoholic Fatty Liver Disease

Mechanism and Therapeutic Targets of c-Jun-N-Terminal Kinases Activation in Nonalcoholic Fatty Liver Disease

Non-alcoholic fatty liver (NAFL) is the most common chronic liver disease. Activation of mitogen-activated kinases (MAPK) cascade, which leads to c-Jun N-terminal kinase (JNK) activation occurs in the liver in response to the nutritional and metabolic stress. The aberrant activation of MAPKs, especi...

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Bibliographic Details
Main Authors: Robert W. M. Min, Filbert W. M. Aung, Bryant Liu, Aliza Arya, Sanda Win
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
JNK
SAB
JNK activation loop
ROS
MAP kinase cascade
drug therapy
Online Access:https://www.mdpi.com/2227-9059/10/8/2035

Internet

https://www.mdpi.com/2227-9059/10/8/2035

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