Disruption of CISH promotes the antitumor activity of human T cells and decreases PD-1 expression levels

Disruption of CISH promotes the antitumor activity of human T cells and decreases PD-1 expression levels

Tumor cells and the immunosuppressive tumor microenvironment suppress the antitumor activity of T cells through immune checkpoints, including the PD-L1/PD-1 axis. Cytokine-inducible SH2-containing protein (CISH), a member of the suppressor of cytokine signaling (SOCS) family, inhibits JAK-STAT and T...

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Bibliographic Details
Main Authors: Jiang Lv, Le Qin, Ruocong Zhao, Di Wu, Zhiping Wu, Diwei Zheng, Siyu Li, Mintao Luo, Qiting Wu, Youguo Long, Zhaoyang Tang, Yan-Lai Tang, Xuequn Luo, Yao Yao, Li-Hua Yang, Peng Li
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
chimeric antigen receptor T cells
immunotherapy
CISH
PD-1
FBXO38
CRISPR-Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522001516

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http://www.sciencedirect.com/science/article/pii/S2372770522001516

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