Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure

Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure

Abstract Background CD34+ cells have been used to treat the patients with heart failure, but the outcome is variable. It is of great significance to scrutinize the fate and the mechanism of CD34+ cell differentiation in vivo during heart failure and explore its intervention strategy. Methods We perf...

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Bibliographic Details
Main Authors: Luping Du, Xiaotong Sun, Hui Gong, Ting Wang, Liujun Jiang, Chengchen Huang, Xiaodong Xu, Zhoubin Li, Hongfei Xu, Liang Ma, Weidong Li, Ting Chen, Qingbo Xu
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Stem Cell Research & Therapy
Subjects:
CD34+ cells
Single-cell RNA sequencing
Lineage tracing
Myocardial fibrosis
Heart failure
Online Access:https://doi.org/10.1186/s13287-023-03256-0

Internet

https://doi.org/10.1186/s13287-023-03256-0

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