Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation

Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation

Abstract Background Neutrophil extracellular trap (NET) formation has been described to be closely involved in the pathogenesis of systemic lupus erythematosus (SLE). In this study, we aimed to investigate the effect of polydatin (PD) on NET formation and its effects on disease activity in lupus-pro...

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Bibliographic Details
Main Authors: Pan Liao, Yi He, Fangyuan Yang, Guihu Luo, Jian Zhuang, Zeqing Zhai, Lili Zhuang, Zhuomiao Lin, Jiehuang Zheng, Erwei Sun
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Arthritis Research & Therapy
Subjects:
Neutrophil extracellular trap
NETosis
Reactive oxygen species
Systemic lupus erythematosus
Polydatin
Online Access:http://link.springer.com/article/10.1186/s13075-018-1749-y

Internet

http://link.springer.com/article/10.1186/s13075-018-1749-y

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