Polygenic risk score-based phenome-wide association study of head and neck cancer across two large biobanks

Polygenic risk score-based phenome-wide association study of head and neck cancer across two large biobanks

Abstract Background Numerous observational studies have highlighted associations of genetic predisposition of head and neck squamous cell carcinoma (HNSCC) with diverse risk factors, but these findings are constrained by design limitations of observational studies. In this study, we utilized a pheno...

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Bibliographic Details
Main Authors: Young Chan Lee, Sang-Hyuk Jung, Manu Shivakumar, Soojin Cha, Woong-Yang Park, Hong-Hee Won, Young-Gyu Eun, Penn Medicine Biobank, Dokyoon Kim
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Medicine
Subjects:
Head and neck cancer
Polygenic risk score
Phenome-wide association study
Smoking
Alcohol consumption
Human papillomavirus
Online Access:https://doi.org/10.1186/s12916-024-03305-2

Internet

https://doi.org/10.1186/s12916-024-03305-2

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