Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun

Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun

Abstract The Src-family tyrosine kinase Lck is an enzyme associated with the CD4 and CD8 co-receptors and promoting signaling through the T cell receptor (TCR) complex. The levels of Lck expression and activity change during the development and differentiation of T cells. Here we show that Lck expre...

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Bibliographic Details
Main Authors: Yury V. Shebzukhov, Silke Stanislawiak, Taisiya R. Bezhaeva, Sergei A. Nedospasov, Dmitry V. Kuprash
Format: Article
Language:English
Published: Nature Portfolio 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02553-y

Internet

https://doi.org/10.1038/s41598-017-02553-y

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