5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells

5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells

5-Azacytidine (5-azaC), a methyltransferase inhibitor and anticancer drug, can promote several cellular stress responses such as apoptosis, autophagy, and senescence. The action of 5-azaC is complex and can be modulated by dose, time of treatment, and co-administration with oxidants. Insulinoma is a...

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Bibliographic Details
Main Authors: Kamila Filip, Anna Lewińska, Jagoda Adamczyk-Grochala, Antonella Marino Gammazza, Francesco Cappello, Marianna Lauricella, Maciej Wnuk
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
5-azacytidine
oxidative stress
insulinoma
Trdmt1
nitric oxide
autophagy
Online Access:https://www.mdpi.com/2073-4409/11/7/1213

Internet

https://www.mdpi.com/2073-4409/11/7/1213

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