Isolation of High-Purity Extracellular Vesicles by the Combination of Iodixanol Density Gradient Ultracentrifugation and Bind-Elute Chromatography From Blood Plasma

Isolation of High-Purity Extracellular Vesicles by the Combination of Iodixanol Density Gradient Ultracentrifugation and Bind-Elute Chromatography From Blood Plasma

Background: Extracellular vesicles (EVs) (isolated from blood plasma) are currently being extensively researched, both as biomarkers and for their therapeutic possibilities. One challenging aspect to this research is the efficient isolation of high-purity EVs from blood plasma in quantities sufficie...

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Bibliographic Details
Main Authors: Zsófia Onódi, Csilla Pelyhe, Csilla Terézia Nagy, Gábor B. Brenner, Laura Almási, Ágnes Kittel, Mateja Manček-Keber, Péter Ferdinandy, Edit I. Buzás, Zoltán Giricz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
extracellular vesicles
isolation
exosomes
plasma
iodixanol
density gradient ultracentrifugation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01479/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01479/full

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