BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells

BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells

Abstract Background Excessive hepatic glycogen accumulation benefits tumorigenesis and cancer cell survival. We previously reported that BMP4 has the strongest ability to promote glycogenesis among the 14 BMPs in hepatocytes and augmented hepatocellular carcinoma (HCC) cell survival under hypoxia an...

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Bibliographic Details
Main Authors: Jiamin Zhong, Luyao Tian, Yannian Gou, Piao Zhao, Xiangyu Dong, Meichun Guo, Guozhi Zhao, Aohua Li, Ailing Hao, Tong-Chuan He, Jiaming Fan
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cancer & Metabolism
Subjects:
HCC
BMP4
SLC2A1
Smad signal pathway
Glycogen synthesis
Online Access:https://doi.org/10.1186/s40170-023-00310-6

Internet

https://doi.org/10.1186/s40170-023-00310-6

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