The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification

The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification

The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that th...

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Bibliographic Details
Main Authors: Thibault Bouderlique, Lucia Peña-Pérez, Shabnam Kharazi, Miriam Hils, Xiaoze Li, Aleksandra Krstic, Ayla De Paepe, Christian Schachtrup, Charlotte Gustafsson, Dan Holmberg, Kristina Schachtrup, Robert Månsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
E-protein
lymphoid specification
hematopoiesis
humoral immunity
evolution
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00455/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00455/full

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